iSpot - Determination of cellular immune response in various infections.
This test can distinguish between active (specific effector cells) and latent (specific memory cells) infections. Thus, infection, inflammation and autoimmune processes can now be better evaluated.
Whereas. EliSpot is based solely on the production of interferon γ (IFN-gamma), iSpot also detects the cytokine IL-2.
If interferon gamma is positive in iSpot (SI 2-3 weakly positive, >3 positive), this indicates that the sample contains effector T cells responding to the pathogen and the patient likely has an active infection. This indicates the appropriateness of therapy at this time.
If IL2 iSpot is positive (same SI reference ranges), this indicates the presence of pathogen-specific memory cells, i.e., indicating immune memory for past infection.
The physician should make treatment decisions for the patient based on the patient's symptoms. The value of iSpot is that it gives you more information about the patient's immune system response.
In the lab. ArminLabsmethod analysis iSpot is available for the diagnosis of infections caused by pathogens:
