HHV 6 (iSpot)

Описание

В ArminLabs выполняется анализ для определения клеточной активности Вируса герпеса человека 6 типа с помощью сертифицированного метода iSpot

HHV-6 iSpot Humans Herper Virus

Human Herpesvirus 6 (HHV-6), is part of the Betaherpesvirinae and consists of the two human pathogenic species HHV-6A and HHV- 6B. Betaherpesvirinae, are characterized based on their ability to establish a latent infection in monocytes and retain similarities in their genes and genomic structure.
Human Herpesvirus 6 (HHV-6) was first discovered by a working group at the National Institutes of Health in Maryland. Infections with HHV-6 are omnipresent, approaching 80% in seroprevalence for adults. It is demonstrated that most of the infections usually occur during infancy by droplet infection but without significant symptoms. Besides the later discovered human herpes virus type 7, HHV-6 is the only known human herpes virus that primarily infects T-lymphocytes.

HHV-6B is known as the causative agent of Exanthema Subitum (roseola infantum). Primary infections with HHV-6B are a common, but mild, acute febrile disease of infants with a maculopapular rash that resolves spontaneously. The initial infection may be asymptomatic or might cause clinical manifestations other than classic exanthem subitum. Symptoms include otitis, gastrointestinal or respiratory distress, and seizures.
In later stages occurring in healthy children and adults; the virus replicates in the salivary glands and is secreted in saliva without inducing any obvious pathology. It remains latent at least in lymphocytes and monocytes and persists in various tissues, possibly with a low-level replication.

HHV-6B can cause more severe pathologies, especially for immunosuppressed patients. It can infect endothelial cells, liver cells, astrocytes, and oligodendrocytes. HHV-6B is associated with many
diseases, especially neurological diseases-including seizures, encephalitis, and mesial temporal lobe epilepsy(MTLE). It’s linked to contributing also to the pathology of autoimmune disease, cancer, chronic fatigue syndrome, drug hypersensitivity, endocrine conditions, hematological disorders, HIV/AIDS Progression, infertility and miscarriage, kidney disease, liver disease, lung disease, and transplant complications. Active infections with HHV-6 are heavily linked to Alzheimer’s disease.
There’s no evidence for an association between HHV-6A and any diseases. Although HHV-6A DNA and mRNA are found more frequently than HHV-6B in patients with neuroinflammatory diseases such as multiple sclerosis.